Islands are cradles of biodiversity – home to many species found nowhere else on our planet. This project will document the biodiversity of islands located within the iconic yet understudied coastal lands and waters of the Gulf of Maine. Through surveys carried out by academic and community scientists alike, this research will explore the environmental … Read more
Project Summary: Anesthetic arousal is a complex neurological process. For some patients, arousal does not occur as planned, such as during delayed emergence or postoperative delirium, which increases the risk of postoperative complications. Aldehydes, toxic byproducts of oxidative stress, accumulate during anesthesia and disrupt synaptic function, promote neuroinflammation, and impair mitochondrial function. Aldehyde dehydrogenase 2 … Read more
PROJECT SUMMARY/ABSTRACT This proposal details a comprehensive five-year training program investigating mechanisms of immune dysfunction in children with chronic cholestatic liver diseases (CSLD). These diseases are characterized by accumulation of bile acids in circulation and are the leading indication for liver transplantation (LT) in children. Infections cause significant morbidity and mortality in children with chronic … Read more
Project Summary/Abstract: The Myc oncogene is a critical driver of tumorigenesis and is difficult to drug. In particular, ~42% of pancreatic ductal adenocarcinomas (PDAC) have high levels of Myc protein, which correlates with the poorest prognosis. While many cancer studies rely solely on transcriptomic analyses, RNA levels often do not correlate with protein abundance, highlighting … Read more
PROJECT ABSTRACT / SUMMARY The ribosome is a fine-tuned regulator of gene expression through multiple layers of regulation, including post- transcriptional RNA modifications. Cancer cells have “hijacked” the translation machinery to exert rapid and selective translational control of the cancer proteome in a matter that is distinct from normal cells. Changing the landscape of the … Read more
Low-income men experience elevated chronic disease burden and chronic stress, yet few prevention programs are designed to strengthen stress coping, social connection, sleep, and wellbeing in this population. In our previous NIMHD-funded research with low-income men in the U.S. Northeast, stress emerged as a key link between unemployment, housing insecurity, limited social support, stress-related behavioral … Read more
Immediately following animal fertilization, embryonic cells undergo rapid cell divisions to make a multicellular organism. Precise equal separation of duplicated DNA into two daughter cells is crucial during early development. If tight regulation of cell divisions does not occur in the early embryo, it can cause developmental defects, birth defects, or embryo death. This project … Read more
Project Summary/Abstract Basal bodies are large protein complexes that template cilia and organize the cytoskeleton. Defects in basal bodies contribute to both cancer and ciliopathies. Ciliopathies are human syndromic diseases that include brain malformations, mental retardation, polydactyl, blindness, obesity, and defective kidneys. Cilia are key for multiple functions that include respiratory function, fertility, and establishment … Read more
PROJECT SUMMARY The mission of the Cellular and Molecular Medicine (CMM) Ph.D. program is to train the next generation of the biomedical workforce at the translational interface between basic biomedical science and clinical research. CMM is designed from the ground-up as an independent, stand-alone Ph.D. granting program. CMM trainees will receive unique and tailored training … Read more
Scientific research today generates data at a scale and pace that far exceeds what most research institutions can manage on their own. Petabytes of measurements from telescopes, particle accelerators, weather sensors, and medical imaging systems sit in disconnected storage systems across the country, out of reach of many scientists who could use them to drive … Read more