Flipping the Switch in Cell Cycle Control: Dissecting the Molecular Mechanisms Governing Wee1 Kinase transition from Cdk Inhibitor to Substrate
Abstract Cell cycle checkpoints are essential for maintaining genomic integrity, and their dysregulation is a hallmark of cancer. Among these, the G2-to-M transition is regulated by the kinase WEE1, which delays mitotic entry by phosphorylating and inactivating Cdk1. This modification prevents cell division under conditions of DNA damage or replication stress. Paradoxically, at the G2–M … Read more