Modelling & Data Analysis – Page 2

Leveraging Sexually TransmittedInfection Data for Enhancing HIV Prevention and Management Guidelines: A Data Science Approach

Despite significant advancements in HIV prevention and treatment, there remains a critical gap in integrating sexually transmitted infection (STI) data into predictive models for HIV health care-related outcomes. STIs have been recognized as significant risk factors for HIV acquisition and poor HIV care outcomes through a range of biological (e.g., mucosal barrier disruption and inflammatory … Read more

Structure and conformational dynamics of membrane-associated HIV-1 antisense protein ASP to aid viral entry

PROJECT SUMMARY Pandemic HIV-1 group M strains encode an antisense protein (ASP) of ~189 amino acids and with a molecular weight ~20 kilodaltons (kDa). Expression of ASP is driven by a constitutive, Tat-independent negative sense promoter in the 3’ long terminal repeat (LTR). The presence of cellular and humoral immune responses against ASP in peripheral … Read more

E-RISE: Nebraska Center for 3D Innovation (NE3D)

The Nebraska Center for 3D Innovation (NE3D) is a multidisciplinary initiative designed to advance biomedical research, education, and workforce development by expanding fundamental knowledge in biomimetic design, additive manufacturing, and digital modeling. Through three core research goals—biomimetic prosthetic systems and actuation, antimicrobial materials for additive manufacturing, and AI-driven anatomical modeling—NE3D seeks to explore novel structure-function … Read more

CAREER: Modeling Trust Dynamics and System Adaptation for Human-AI Collaboration in Engineering Design

This Faculty Early Career Development Program (CAREER) project supports research and education focused on trust in human-artificial intelligence (AI) collaboration during early-stage engineering design. In open-ended, creative design contexts, trust governs how designers engage with and rely on AI-generated suggestions, yet this reliance is often implicit, context-dependent, and difficult to capture by traditional acceptance-based or … Read more

Signaling in the Aphid-Buchnera Endosymbiosis: Maintaining Homeostasis Within and Across Generations

Beneficial bacteria that live inside insect cells are widespread in nature and have persisted in partnerships with their hosts for tens to hundreds of millions of years. Despite their importance – many insects cannot survive or reproduce without them – scientists know surprisingly little about how host cells maintain normal function while housing a resident … Read more

RESEARCH-PGRP: BIO-AI: Genomic Drivers and Functional Implications of Plant Transcription Start Site Selection

Every cell in a plant carries the same genetic blueprint, yet different cells use that blueprint in different ways, a process controlled by where and how genes begin to be read, or transcribed. This starting point, known as the transcription start site (TSS), acts like a switch that determines not only when a gene turns … Read more

Environmental drivers and consequences of lekking by white bearded manakins

This project advances our ability to address a growing need in the field of behavioral ecology: how high-dimensional, correlated social and ecological variables interact to shape animal behaviors in the natural world. To meet this need, our team of AI experts and seasoned behavioral ecologists will pioneer the development of two complementary computational tools – … Read more

Collaborative Research: Change Point Testing and Estimation with Irregular Signals

The project aims to advance the field of statistical change-point detection by developing novel methods and their associated theory to handle complex data with irregular signals. Unlike the traditional setting in which signals before and after the change point are often assumed to differ by a constant shift, irregular signals refer to the situation when … Read more

FET: Toward Rewritable and Distributed In Vivo DNA Data Storage Networks

This project addresses the critical challenge of global data storage by developing a sustainable, high-density alternative to traditional silicon-based hard drives. While DNA has long been recognized as a powerful medium for long-term data preservation, existing technologies are often slow and limited to “write-once” applications, like an old-fashioned CD-ROM. This research aims to overcome these … Read more

Predoctoral Training in Quantitative Cell & Molecular Biology

The Quantitative Cell and Molecular Biology (qCMB) Training Program provides comprehensive and flexible training in quantitative approaches in order to facilitate cross-disciplinary and collaborative research in the broad field of Cell & Molecular Biology. The Program produces outstanding graduates with the skills to meet the computational and professional demands of modern life science research. The … Read more